The Carpathian-Pannonian region is one of the areas of Central Europe with good coverage of geophysical and geological data. This is due to its complicated evolution that attracted scientific interest already in the past. In addition, several international seismic experiments were conducted here in the last 10 years. The model to be presented uses most of these available data to perform a combined gravity–seismic interpretation. The analysis of the gravity anomalies is performed in order to identify the sources of the anomalies, separate their effects and localize the lithospheric inhomogeneities. The gravity stripped image of the region reveals significant differences in the nature of the Microplates ALCAPA and Tisza-Dacia from the surrounding regions.