U–Pb zircon and U–Th–Pb EPMA monazite dating of one metamafic sample and two metapelitic samples are studied from Karakoram Metamorphic Complex, Hunza NW Pakistan. These new geochronological results address the collision–related metamorphic evolution of the thickened Asian Plate crust with the Kohistan Island Arc and then with the Indian Plate. Following the collision and accretion of the Kohistan Island Arc during the Late Cretaceous, the Karakoram Metamorphic Complex experienced crustal thickening and sillimanite–grade metamorphism at the southern apex. Two new chronological events have been recorded in the investigated Hunza Valley region. U–Pb zircon ages of 103.1 ± 2.9 Ma and 100.0 ± 5.3 Ma represent the peri–plutonic thermal metamorphism before the India–Asia collision, whereas U–Th–Pb monazite age of 47 ± 4.3 Ma documents the peak sillimanite grade metamorphism with ongoing India–Asia collision. These zircon ages of the metamorphic crystallization are inferred to be related to the subduction of the Tethys Ocean beneath the southern Asian margin which finally led to the south-ward collisional thrusting of the Cretaceous Hunza Plutonic Unit of the Karakoram Batholith in the Hunza Valley over the Karakoram Metamorphic Complex in the Eocene. Crustal thickening and the metamorphic evolution from sillimanite to kyanite to staurolite grade and granitoid magmatism are related with the Kohistan Island Arc–Asia and the India–Asia collision zones.