The mid-Cretaceous onset of the Alpine uplift of previously burried pre-Tertiary basement and cover rock units is recorded in the southern Central West Carpathian zones in the Veporic superunit. The Meso-Cenozoic collisional processes gradually continued by the uplift of more external Tatric units during the Paleogene, Neogene and Quaternary. Based on the paleo-Alpine values of Rb-Sr, Ar-Ar, K-Ar and FT datings, the south to north Veporic and southernmost Tatric (Nizke Tatry Mts.) zones began to be uplifted from the depth levels of ca. 20 km (T = 350–450 °C) 120–90 Ma ago. They reached ca. 100 °C 90–55 Ma ago which indicates an average uplift rate of about 0.5 mm/year. To the contrary, the Tatric pre-Alpine complexes have been not buried deeper than 12 km (ca. 250 °C) after the Permian. Their uplift is documented by zircon and apatite FT data. It started from depths of 10–11 km (225 °C) about 70–50 Ma ago and reached the 5 km (100 °C) depth level 30–15 Ma ago. Accordingly, the average uplift rate was 0.1–0.2 mm/year. Besides the time differences, the dynamic background of uplift in the Veporic and Tatric zone was also apparently different. The impacts of distinct tectonic regimes on the modes of uplift, namely the tectonic unroofing of metamorphic domes vs. block rotation in wrench zones, are briefly discussed.