The following types of ore mineralization are distinguished in the Male Karpaty Mts.: I — metamorphosed, primarily exhalation-sedimentary pyrite; II — hydrothermal-molybdenum, polymetallic and antimony-gold; III — copper-barite and uranium in the Upper Paleozoic; IV — sedimentary-manganese; V — gold placers. Pyrite and antimony-gold mineralization are the most frequently occurring ones and spatially as well as genetically related. The metals could have been mobilized from Paleozoic black schists, metavolcanites and metasediments by fluids released in the process of pre-intrusive regional metamorphism or during the intrusion of granitoids. Negative values of δ³⁴S as well as the values of δ¹⁸O and δ¹³ C and their distribution indicate intensive interaction of ore-bearing solutions with the surrounding rock environment. Homogenization temperatures of fluid inclusions in quartz (320–150 °C) confirm the succession on the formation of the distinguished Sb-Au mineralization parageneses. The formation of copper-barite mineralization is connected with Permian volcanism, and the origin of uranium mineralization with the circulation of groundwaters. Sedimentary Mn-mineralization occurs in Jurassic shales.