The contribution presents a model of metallogenic evolution of the Bohemian Massif. The model has been developed on the basis of an analysis of mineral and element assemblages. It describes the evolution of individual metallogenic systems in relation to the block structure. Clustering statistical methods have been applied in the development of the model. The temporal evolution has been derived from the evaluation of isotopic composition of lead and it has been correlated with other geochronological methods. From the interpretation of the model it follows that the metallogenic evolution was irregular, the character of crust and activation of the block having been different in different times. Marked features are repeating of metallogenic activities, multiphase evolution and regeneration, prominent especially in peripheral blocks. From the Moravian-Silesian group of blocks metallogenic point of view considerably differs from the rest of the Bohemian Massif.